Genes Involved

FoxF1 Gene

This gene provides the instructions for making a protein known as the forkhead box protein, which contributes to the activity of several other genes.

However, it isn't known how involved the FoxF1 gene is with the development of GERD. The gene is seen to affect the development of Barrett's Esophagus, which is seen to be most commonly a complication of long-term GERD.

Also to note, GERD, Barrett's Esophagus, and Esophageal Cancer overlap and relate to one another directly. Because of this, it is strongly possible that the FoxF1 gene plays a role in the development of possibly all three diseases.

GNB3 C825T Variant

This polymorphism affects the production of the GNB3 G protein, which functions in transmitting signals between other proteins.

In a study testing the genetics behind GERD, all patients diagnosed with GERD had the variant detected while the control had many without the variant.

While genetics have been identified in relation to the development of GERD, the disease itself is mostly based on the quality of lifestyle. From the foods we eat to how much we exercise many factors influence how severe the GERD can be. Even if this disease is a result of genetics, it is still important to maintain a healthy lifestyle, which will decrease the prevalence and severity of the GERD.